Table 3—

Prognostic value of a marginal decline(5–10% change) in forced vital capacity (FVC) when patients with a significant decline (>10% change) were excluded, controlled for disease severity

HR (95% CI)p-valueHR (95% CI)p-value
5–10% decline FVC univariate2.31 (1.19–4.50)0.0141.36 (0.40–4.66)0.62
5–10% decline FVC DL,CO controlled3.33 (1.61–6.88)<0.0011.46 (0.42–5.00)0.55
5–10% decline FVC CPI controlled3.60 (1.70–7.62)<0.0011.29 (0.38–4.42)0.69
  • Significant (p<0.05) relationships are shown, with hazard ratios (HR), expressing the difference in risk of mortality between those with change and those without (with 95% CI). In idiopathic pulmonary fibrosis (IPF), mortality was higher with both marginal and significant decline than in stable disease when controlled for baseline disease severity (p<0.005), with no difference in mortality between patients with a marginal decline in FVC and those with a significant decline in FVC (both p<0.001). A marginal decline in FVC did not predict mortality in non-specific interstitial pneumonia (NSIP). DL,CO: diffusing capacity of the lung for carbon monoxide; CPI: composite physiological index. #: n = 84; : n = 72.