Prognostic value of a marginal decline(5–10% change) in forced vital capacity (FVC) when patients with a significant decline (>10% change) were excluded, controlled for disease severity
| IPF# | NSIP¶ | |||
| HR (95% CI) | p-value | HR (95% CI) | p-value | |
| 5–10% decline FVC univariate | 2.31 (1.19–4.50) | 0.014 | 1.36 (0.40–4.66) | 0.62 |
| 5–10% decline FVC DL,CO controlled | 3.33 (1.61–6.88) | <0.001 | 1.46 (0.42–5.00) | 0.55 |
| 5–10% decline FVC CPI controlled | 3.60 (1.70–7.62) | <0.001 | 1.29 (0.38–4.42) | 0.69 |
Significant (p<0.05) relationships are shown, with hazard ratios (HR), expressing the difference in risk of mortality between those with change and those without (with 95% CI). In idiopathic pulmonary fibrosis (IPF), mortality was higher with both marginal and significant decline than in stable disease when controlled for baseline disease severity (p<0.005), with no difference in mortality between patients with a marginal decline in FVC and those with a significant decline in FVC (both p<0.001). A marginal decline in FVC did not predict mortality in non-specific interstitial pneumonia (NSIP). DL,CO: diffusing capacity of the lung for carbon monoxide; CPI: composite physiological index. #: n = 84; ¶: n = 72.