Table 4—

Change in health-related quality of life by exacerbation group at 1 yr

NoneUnreported onlyReported onlyMixed#
1>11>1
Subjects n1673045704692
1-yr change in SGRQ score
 Symptom-13.0±19.2-16.2±18.0-7.2±18.5-2.1±18.5+2.9±14.6+-0.8±21.0+
 Activity-3.7±19.4-4.4±18.81.1±17.22.2±17.2*7.4±17.6**2.8±17.1**
 Impact-6.6±20.6-6.8±18.3-1.5±17.2-3.8±18.92.5±18.7**-3.7±18.8
 Total-6.8±16.7-7.7±13.1-1.6±15.3-1.7±15.0+4.1±14.6+-1.2±15.0**
1-yr change in SGRQ score of ≥4
 Symptom22 (13.4)2 (6.7)9 (20.0)27 (38.6)+26 (56.5)**39 (41.0)+
 Activity47 (28.6)7 (23.3)19 (42.2)27 (38.6)28 (60.9)**44 (46.3)**
 Impact38 (23.2)6 (20.0)14 (31.1)19 (27.1)20 (43.5)+30 (31.6)
 Total32 (19.5)3 (10.0)13 (28.9)21 (30.0)23 (50.0)**28 (29.5)*
  • Data are presented as mean±sd or n (%), unless otherwise indicated (n = 450). SGRQ: St George's Respiratory Questionnaire. #: unreported (≥1) and reported (≥1); : an increase in SGRQ score represents a deterioration in health-related quality of life and vice versa. *: p<0.05; **: p<0.01; +: p<0.0001 versus no exacerbations (reference) using unpaired two-tailed t-test for comparison of continuous variables (two means) and Chi-squared test for comparison of categorical variables (two proportions).