Comparison of changes in vital capacity
| Crude mean±sd | Comparison of adjusted means based on ANCOVA# | |||||||
| Baseline L | Subjects n | 52 weeks L | Subjects n | Subjects n | Adjusted mean±se | Difference from placebo mean±se L | p-value | |
| High dose | 2.40±0.64 | 106 | 2.36±0.73 | 67 | 104 | -0.09±0.02 | 0.07±0.03 | 0.0416 |
| Low dose | 2.44±0.68 | 55 | 2.34±0.71 | 38 | 54 | -0.08±0.03 | 0.09±0.04 | 0.0394 |
| Placebo | 2.47±0.70 | 104 | 2.42±0.75 | 72 | 103 | -0.16±0.02 | ||
#: negative and positive of the changes represent deterioration and improvement from baseline, respectively. Covariates: baseline vital capacity.