Anthropometric characteristics, 8-isoprostane concentrations, spirometric parameters and exhaled nitric oxide values in children with problematic and well-controlled asthma
| Problematic asthma | Well-controlled asthma | p-value | |
| Subjects (males) n | 7 (4) | 13 (7) | |
| Age (range) yrs | 9.6 (6–13) | 11.1 (6–15) | |
| Height cm | 140.6±6.3 | 146.8±3.1 | |
| Weight kg | 35.6±3.9 | 45.8±3.6 | |
| 8-isoprostane in EBC by GC/NICI-MS pg·mL−1 | 68.0±10.3 | 32.8±6.6 | 0.008 |
| 8-isoprostane in EBC by EIA pg·mL−1 | 74.0±12.5 | 35.3±7.4 | 0.01 |
| 8-isoprostane in urine EIA ng·mmol−1 creatinine | 35.4 (30.6–60.6) | 50.6 (35.1–74.9) | 0.44 |
| FVC % pred | 89±6 | 96±3 | 0.26 |
| FEV1 % pred | 76±5 | 89±3 | 0.048 |
| FEF25–75% % pred | 59±7 | 82±7 | 0.05 |
| FEV1/FVC % | 79±4 | 84±2 | 0.20 |
| FeNO ppb | 16 (9.5–47.5) | 27 (17.3–48.0) | 0.36 |
Data are expressed as mean±sem and median (interquartile range), unless otherwise stated. EBC: exhaled breath condensate; GC/NICI-MS: gas chromatographic/negative ion chemical ionisation mass spectrometry; EIA: enzymatic immunoassay; FVC: forced vital capacity; % pred: % predicted; FEV1: forced expiratory volume in 1 s; FEF25–75%: forced expiratory flow between 25% and 75% of FVC; FeNO: exhaled nitric oxide fraction.