Table 1—

Duchenne muscular dystrophy(DMD) patients’ characteristics and pulmonary function test results

AllGroup IGroup IIGroup IIIGroup IVp-value
Patients n6613231515
Age yrs12.64±0.636.23±0.5910.74±0.2414.73±0.3219.00±0.50
Height cm145.65±2.68115.77±6.63142.00±1.90161.50±2.30162.30±2.80<0.001
Weight kg45.16±2.5323.54±4.0444.18±2.6753.93±4.1658.47±4.73<0.001
BMI20.37±0.6417.36±1.9221.55±0.9320.45±1.2621.84±1.26ns
Spirometry
 Patients n55231515
 FVC L1.60±0.081.63±0.071.74±0.201.52±0.17ns
 FVC % pred53.30±2.8166.81±2.7847.27±5.3939.00±4.95<0.001
 FEV1 L·s−11.41±0.071.50±0.071.45±0.181.27±0.15ns
 FEV1 % pred56.67±3.3273.24±3.2648.60±5.9839.07±5.75<0.001
 FEV1/FVC %86.3±1.691.9±1.1584.1±2.780.1±4.50.014
 PEF L·s−12.77±0.132.93±0.152.70±0.292.68±0.33ns
 PEF % pred50.74±2.8963.71±3.3243.00±4.3036.73±5.41<0.001
Lung volume
 TLC L2.82±0.122.54±0.102.91±0.313.28±0.230.043
 TLC % pred68.98±2.7176.00±2.7462.00±6.2664.40±5.71ns
 RV L1.17±0.080.87±0.061.12±0.131.69±0.16<0.001
 RV % pred117.89±6.26106.43±6.74108.73±12.33141.33±14.64ns
 FRC N2 L1.59±0.091.25±0.071.57±0.172.18±0.18<0.001
 FRC N2 % pred81.21±3.7082.38±4.4170.13±7.5387.47±8.29ns
Sp,O2 %#
 Patients n5312161114
 100–9591.53±2.4798.67±0.4779.25±9.6184.45±8.8584.43±5.550.014
 94–907.68±2.211.33±0.472.25±0.7212.73±7.3914.93±5.460.008
 <900.79±0.550.00±0.000.13±0.092.82±2.620.64±0.37ns
  • Data are presented as mean±sem, unless otherwise stated. BMI: body mass index; FVC: forced vital capacity; % pred: % predicted; FEV1: forced expiratory volume in 1 s; PEF: peak expiratory flow; TLC: total lung capacity; RV: residual volume; FRC N2: functional residual capacity assessed by N2 washout; Sp,O2: arterial oxygen saturation measured by pulse oximetry; ns: nonsignificant. #: percentage of the night-time spent with Sp,O2. p-values refer to one-way ANOVA.