Table 1—

Talc and apoptosis of pleural mesothelial cells and lung adenocarcinoma

AgentApoptosis measurement#
Lung adenocarcinomaPleural mesothelial cells
0 h24 h48 h72 h0 h24 h48 h72 h
Talc
 25 μg·mL10.21.66.212.00.10.10.30.6
 50 μg·mL−10.25.99.616.00.10.10.11.4
 75 μg·mL−10.25.916.426.20.10.10.21.6
Bleomycin
 25 μg·mL−10.10.21.52.40.10.10.62.1
 50 μg·mL−10.20.22.22.50.10.11.02.5
 75 μg·mL−10.50.52.33.70.10.31.53.0
Doxycycline
 25 μg·mL−10.211.216.423.10.11.49.612.6
 50 μg·mL−10.233.133.446.50.110.114.219.2
 75 μg·mL−10.139.445.071.50.614.117.827.6
Silicone beads
 25 μg·mL−10.10.10.10.10.10.10.10.1
 50 μg·mL−10.10.20.10.10.10.10.10.7
 75 μg·mL−10.10.20.10.10.10.30.10.8
  • Data are presented as % and represent the median of three independent studies. Experiments were performed in triplicates at each time-point and for each cell line. #: apoptosis of lung cancer cells and pleural mesothelial cells was measured with propidium iodide staining and flow cytometric analysis.