Table 4—

Lung function and cognition in chronic obstructive pulmonary disease(COPD) patients

First author [Ref.]Patients nDescriptionMeasuresCorrelations
Lung functionCognition
Fix 2566LongitudinalHypoxic COPDFEV1NPTAttention, vis-motor and perception
Grant 3203Case controlHypoxaemic COPDFEV1NPTNil
Prigatano 26100COPD mild hypoxia form IPPB trialFEV1NPTMemory
Incalzi 4384Prospective COPDFEV1MMSEDecline in MMSEworse in severe airflow obstruction
Kozora 2832Mildly hypoxic COPDFull PFTNPTNil
Etnier 4498Older COPD mild disease and hypoxiaFull PFTNPTFVC associated with working memory6MWT associated with fluid intelligence and processing speed
Antonelli-Incalzi 45381COPDGOLD stageNPT/MMSENil
Liesker 2930Non-hypoxaemicFEV1NPTNil
Case control
Ohrui 46135Respiratory failure on LTOT versus healthy cross sectionFEV1MMSENil
  • FEV1: forced expiratory volume in 1 s; NPT: neuropsychological tests; IPPB: intermittent positive pressure breathing; MMSE: mini mental score examination; PFT: pulmonary function tests; FVC: forced vital capacity; 6MWT: 6-min walk test; GOLD: Global Initiative for Chronic Obstructive Lung Disease; LTOT: long-term oxygen therapy.