Table 3—

Lung function and cognition in healthy populations

First author [Ref.]Patients nDescriptionMeasuresSignificant associations
Lung functionCognition
Cook 341354Cross sectionHealthy elderlyPEFRNPTTotal cognitive score and memory
Albert 351192LongitudinalHealthy, elderlyPEFRNPT/MMSESecond best predictor of decline in MMSE
Chyou 363036Longitudinal Japanese American males (3 yrs)FEV1CASIBaseline FEV1 (more pronounced in >55 yr olds)
Cerhan 3714000Cross sectionMiddle-aged adultsFEV1NPTInformation processing speed and word fluency
Emery 38444LongitudinalSwedish twin studyFEV1NPT“Fluid intelligence” but not a predictor of cognitive decline
Anstey 392551HealthyLongitudinalAll agesFEV1NPTMemoryReaction time
Aleman 40400Cross section mid age to elderly malesPEFRNPT/MMSE <26PEFR associated with MMSEVascular risk factors associated with processing speedMMSE associated with PEFR
Sachdev 41469HealthyFEV1NPTInformation processing
Cross sectionMotor dexterity
Allaire 42396Cross sectionHealthy African American malesAll agesPEFRTelephone cognitive testsPEFR contributed to 2% variance of cognition in elderly only
  • PEFR: peak expiratory flow rate; NPT: formal neuropsychological testing; MMSE: mini mental score examination; FEV1: forced expiratory volume in 1 s; CASI: cognitive ability screening instrument.