Table 5—

Difference(tiotropium–control) in St George's Respiratory Questionnaire domains at 6 and 48 months

	6 months				48 months
	Tiotropium	Control	Difference	p-value	Tiotropium	Control	Difference	p-value
Total score
Continuing smokers	308	297	−5.43 (−7.06– −3.80)	<0.0001	207	189	−4.63 (−7.26– −2.00)	<0.001
Intermittent smokers	717	639	−2.09 (−3.29– −0.89)	0.0006	543	459	−0.60 (−2.39–1.19)	0.514
Continuing ex-smokers	1428	1375	−2.70 (−3.58– −1.83)	<0.0001	1037	916	−2.74 (−3.99– −1.48)	<0.001
Impact score
Continuing smokers	308	297	−5.09 (−7.00– −3.19)	<0.001	207	189	−4.15 (−7.12– −1.17)	0.007
Intermittent smokers	717	639	−1.95 (−3.33– −0.58)	0.0054	543	459	−0.53 (−2.49–1.44)	0.6
Continuing ex−smokers	1428	1375	−2.17 (−3.15– −1.19)	<0.0001	1037	916	−2.40 (−3.77– −1.03)	<0.001
Symptom score
Continuing smokers	313	301	−6.02 (−8.66– −3.38)	<0.0001	210	192	−4.67 (−8.40– −0.95)	0.014
Intermittent smokers	739	654	−2.72 (−4.68– −0.77)	0.0064	555	478	0.39 (−2.10–2.88)	0.761
Continuing ex-smokers	1449	1405	−4.09 (−5.46– −2.72)	<0.0001	1057	933	−2.15 (−3.94– −0.36)	0.019
Activity score
Continuing smokers	308	297	−6.17 (−8.31– −4.03)	<0.0001	207	189	−5.69 (−8.67– −2.70)	<0.001
Intermittent smokers	717	639	−2.24 (−3.69– −0.80)	0.0024	543	459	−1.49 (−3.63–0.66)	0.173
Continuing ex-smokers	1428	1375	−2.71 (−3.80– −1.63)	<0.0001	1037	916	−3.46 (−4.96– −1.96)	<0.001

Data are presented as n or mean (95% confidence interval), unless otherwise indicated.