Table 6—

Association of matrix metalloproteinase(MMP) single nucleotide polymorphisms and progression free survival (PFS) or overall survival (OS) in early and late-stage small cell lung cancer (SCLC) and nonsmall cell lung cancer (NSCLC)

PolymorphismGenotypesPFSOS
SCLCNSCLCSCLCNSCLC
Stage IIB+IIIA (n = 24)Stage IIIB+IV (n = 106)Stage IIIA (n = 16)Stage IIIB+IV (n = 169)Stage IIB+IIIA (n = 24)Stage IIIB+IV (n = 106)Stage IIIA (n = 16)Stage IIIB+IV (n = 169)
MMP1
 1G-16072GG/G1 (ref)1 (ref)1 (ref)1 (ref)1 (ref)1 (ref)1 (ref)1 (ref)
G/GG+0.4 (0.1–1.2)0.9 (0.5–1.5)0.3 (0.0–3.2)0.7 (0.5–1.1)0.1 (0.0–0.60)#0.8 (0.5–1.4)0.7 (0.1–6.7)1.0 (0.7–1.5)
GG/GG
MMP2
 C-735TCC1 (ref)1 (ref)1 (ref)1 (ref)1 (ref)1 (ref)1 (ref)1 (ref)
CT+TT1.0 (0.4–3.4)0.7 (0.4–1.1)0.6 (0.1–4.9)0.9 (0.6–1.4)0.6 (0.1–4.9)0.9 (0.6–1.4)0.9 (0.1–8.7)1.0 (0.6–1.6)
MMP3
 6A-1171 5A6A 6A1 (ref)1 (ref)1 (ref)1 (ref)1 (ref)1 (ref)1 (ref)1 (ref)
6A 5A+5A 5A1.7 (0.2–13.1)1.3 (0.8–2.2)1. 6 (0.3–8.2)0.9 (0.6–1.4)1.6 (0.2–13.2)1.1 (0.7–1.9)2.0 (0.2–18.0)0.9 (0.6–1.5)
MMP7CC1 (ref)1 (ref)1 (ref)1 (ref)1 (ref)1 (ref)1 (ref)1 (ref)
 C-153TCT+TT1.9 (0.6–5.9)1.8 (1.0–3.1)1.2 (0.2–6.1)0.7 (0.4–1.1)1.5 (0.3–7.3)1.6 (0.9–2.8)0.9 (0.1–8.1)0.7 (0.4–1.2)
 A-181GAA1 (ref)1 (ref)1 (ref)1 (ref)1 (ref)1 (ref)1 (ref)1 (ref)
AG+GG0.7 (0.2–2.5)1.0 (0.5–1.8)N/A1.0 (0.7–1.5)1.7 (0.2–13.0)0.8 (0.4–1.5)N/A1.0 (0.6–3.1)
MMP9
 C-1562TCC1 (ref)1 (ref)1 (ref)1 (ref)1 (ref)1 (ref)1 (ref)1 (ref)
CT+TT0.3 (0.1–1.5)1.7 (1.0–2.9)+1.7 (0.3–8.8)1.2 (0.8–1.8)0.2 (0.0–1.7)1.4 (0.8–2.6)0.5 (0.1–4.0)1.2 (0.8–1.9)
MMP12
 A-82GAA1 (ref)1 (ref)1 (ref)1 (ref)1 (ref)1 (ref)1 (ref)1 (ref)
AG+GG0.3 (0.07–1.44)0.80 (0.5–1.3)0.5 (0.1–4.4)1.1 (0.7–1.6)N/A0.6 (0.3–1.0)§0.5 (0.1–4.6)1.1 (0.7–1.7)
 A1082GAA1 (ref)1 (ref)1 (ref)1 (ref)1 (ref)1 (ref)1 (ref)1 (ref)
AG+GG0.9 (0.2–3.9)1.4 (0.7–2.7)0.8 (0.1–6.8)1.2 (0.7–2.3)1.0 (0.1–8.4)1.2 (0.6–2.6)N/A1.2 (0.7–2.2)
  • Data are presented as hazard ratio (95% CI), unless otherwise stated. Hazard ratios for OS are adjusted for sex. N/A: not applicable. Bold indicates significance. #: p = 0.001; : p = 0.04; +: p = 0.04; §: p = 0.04.