Table 2—

Distribution of 57 cases of lung cancer and 3,749 controls according to lung function measures and corresponding OR with 95% CI

CharacteristicsLung cancer casesControlsOR (95%CI)#OR (95%CI)
COPD+,§
 Negative39 (69.6)2910 (77.6)1.001.00
 Positive17 (30.4)839 (22.4)1.48 (0.82–2.67)1.23 (0.68–2.25)
COPD§,ƒ
 Negative30 (53.6)2390 (63.8)1.001.00
 Positive26 (46.4)1359 (36.2)1.68 (0.99–2.88)1.46 (0.85–2.52)
FEV1 % pred
 ≥9021 (36.8)2640 (70.5)1.001.00
 <9036 (63.2)1107 (29.5)2.94 (1.67–5.16)2.45 (1.39–4.33)
 70–8924 (42.1)849 (22.7)2.72 (1.48–4.97)2.29 (1.24–4.23)
 <7012 (21.1)258 (6.9)3.64 (1.70–7.81)2.90 (1.34–6.27)
 Chi trend (p-value)14.5 (0.0001)9.45 (0.0021)
FEV1 % pred and COPD+,§
 FEV1 ≥90% pred21 (36.8)2640 (70.5)1.001.00
 FEV1 <90% pred without COPD19 (33.3)582 (15.5)2.75 (1.44–5.25)2.36 (1.23–4.52)
 FEV1 <90% pred with COPD17 (29.8)525 (14.0)3.19 (1.63–6.23)2.56 (1.29–5.07)
 Chi trend (p-value)13.4 (0.0003)8.4 (0.0037)
FEV1 % pred and COPD§,ƒ
 FEV1 ≥90% pred21 (36.8)2640 (70.5)1.001.00
 FEV1 <90% pred without COPD14 (24.6)450 (12.0)2.51 (1.24–5.09)2.15 (1.05–4.40)
 FEV1 <90% pred with COPD22 (38.6)657 (17.5)3.28 (1.77–6.09)2.67 (1.42–5.01)
 Chi trend (p-value)14.8 (0.0001)9.6 (0.0019)
  • Data are presented as n (%), unless otherwise stated. COPD: chronic obstructive pulmonary disease; FEV1: forced expiratory volume in 1 s; % pred: % predicted. #: obtained from unconditional logistic regression after adjustment for age, sex and study; : obtained from unconditional logistic regression after adjustment for age, sex, study, smoking status, duration of smoking and number of cigarettes; +: COPD cases had FEV1/forced vital capacity (FVC) index <70% for all subjects; §: the sum does not add up to the total because of missing values; ƒ: COPD cases had FEV1/FVC index index<75% for subjects of age <60 yrs, <70% for subjects aged 60–69 yrs and <65% for subjects aged ≥70 yrs.