Likelihood of asthma at age 6 yrs following frequent nocturnal awakenings at 1 yr and frequent awakenings persisting over a 3-yr period
| Asthma at age 6 yrs | Nonatopic asthma at age 6 yrs | ||
| Frequent nocturnal awakening | At 1 yr | Persistent | Persistent |
| Subjects n | 1999 | 1999 | 1365 |
| Unadjusted OR | 0.98 (0.77–1.24) | 1.19 (0.87–1.62) | 1.58 (0.94–2.65) |
| OR adjusted for ARF and co-sleeping | 1.03 (0.81–1.31) | 1.26 (0.92–1.74) | 1.69 (1.00–2.86) |
| OR adjusted for ARF, co-sleeping and wheeze# | 1.04 (0.81–1.32) | 1.31 (0.95–1.81), p<0.095 | 1.72 (1.01–2.93), p<0.044 |
| OR adjusted for ARF, co-sleeping, wheeze# and family stress | 1.02 (0.79–1.31) | 1.35 (0.97–1.89), p<0.073 | 1.87 (1.08–3.25), p<0.026 |
| OR adjusted for ARF, co-sleeping and family stress, exclude wheeze | 1.14 (0.85–1.53) | 1.51 (1.04–2.20), p<0.032 | 2.78 (1.51–5.09), p<0.001 |
ARF: asthma risk factors. #: wheeze during sleep.