Midazolam (n = 39) | Propofol (n = 43) | Difference (95% CI) | p-value# | |
Global tolerance | ||||
Patient 60 min | 15.2±18.7 | 8.4±11.1 | -6.8 (-13.5–0.1) | 0.051 |
Patient 24 h | 14.3±16.7 | 7.9±8.7 | -6.4 (-0.4– -12.2) | 0.036 |
Operator | 16.2±17.4 | 22.7±24.9 | 6.5 (-2.9–15.9) | 0.171 |
Pain | ||||
Patient 60 min | 8.8±13.0 | 3.9±4.1 | -4.9 (-9.2– -0.6) | 0.026 |
Patient 24 h | 8.1±12.0 | 4.8±4.8 | -3.4 (-7.4–0.7) | 0.106 |
Nausea | ||||
Patient 60 min | 7.7±13.4 | 3.2±4.7 | -4.6 (-9.0– -0.1) | 0.047 |
Patient 24 h | 8.9±15.7 | 4.3±7.0 | -4.6 (-10.0–0.8) | 0.097 |
Breathlessness | ||||
Patient 60 min | 13.3±23.6 | 4.4±5.9 | -9.0 (-16.4– -1.2) | 0.024 |
Patient 24 h | 12.3±20.6 | 5.9±8.2 | -6.4 (-13.4–0.64) | 0.074 |
Cough | ||||
Patient 60 min | 18.4±23.5 | 18.0±20.9 | -0.3 (-10.2– -9.5) | 0.946 |
Patient 24 h | 16.4±19.1 | 18.1±21.3 | 1.6 (-7.3– -10.5) | 0.715 |
Data are presented as mean±sd, unless otherwise stated. VAS: 0 mm corresponds to excellent tolerance and 100 mm to very low tolerance. #: p-values derived from robust linear regression using VAS score difference as dependent variable and group as independent variable.