Table 1—

Lung function, NO parameters and inflammatory markers in exhaled breath condensate(EBC) in 40 patients with chronic obstructive pulmonary disease according to the current smoking status

SmokersEx-smokersp-value
Subjects n2911
Males/females n18/119/20.286#
Post-bronchodilator FEV1 % pred64.6±2.753.3±4.80.037
Post-bronchodilator FEV1/FVC0.54±0.020.43±0.030.002
FEF75% % pred24.7±1.718.7±3.20.084
RV % pred150.7±6.7164.5±17.70.481
Raw % pred190.5±10.4273.6±44.50.096
TL,CO % pred54.8±2.150.3±4.10.309
FeNO0.05 ppb8.8 (5.1–13.5)16.2 (11.5–19.1)0.025+
FeNO0.1 ppb5.2 (3.8–8.2)8.1 (5.8–10.3)0.052+
FeNO0.2 ppb4.2 (3.1–6.2)5.0 (3.8–7.3)0.131+
FeNO0.3 ppb3.6 (2.8–5.6)4.7 (3.9–6.4)0.148+
J′aw,NO nL·s−10.26 (0.07–0.41)0.39 (0.38–0.73)0.025+
J′aw,NO(TMAD) nL·s−10.44 (0.12–0.70)0.66 (0.65–1.24)0.025+
CA,NO ppb3.0 (2.3–3.8)3.3 (2.4–3.6)0.680+
CA,NO(TMAD) ppb2.8 (1.9–3.4)2.5 (1.5–3.6)0.899+
EBC LTB4 pg·mL−16.7 (5.0–9.0)6.4 (4.0–12.3)1.000+
EBC cysLT pg·mL−18.4 (1.0–13.9)6.6 (1.0–12.8)0.824+
EBC 8-isoprostane pg·mL−19.3 (7.3–14.2)10.3 (8.8–17.3)0.280+
  • Data are presented as mean±sem or median (interquartile range), unless otherwise stated. FEV1: forced expiratory volume in 1 s; % pred: % predicted; FVC: forced vital capacity; FEF75%: forced expiratory flow when 75% of vital capacity is exhaled; RV: residual volume; Raw: airway resistance; TL,CO: pulmonary transfer factor for carbon monoxide; FeNOx: fractional exhaled NO concentration at exhalation flow rate of x L·s−1; Jaw,NO: bronchial NO flux; Jaw,NO(TMAD): bronchial NO flux adjusted for trumpet shape airways and axial diffusion; CA,NO: alveolar NO concentration; CA,NO(TMAD): alveolar NO concentration adjusted for trumpet shape airways and axial diffusion; LTB4: leukotriene B4; cysLT: cysteinyl leukotriene. #: Fisher’s exact test for sex-distribution between smokers and ex-smokers; : unpaired t-test between smokers and ex-smokers; +: Mann–Whitney U-test between smokers and ex-smokers. Values in bold are statistically significant.