Table 3—

Pattern of differentially regulated biomarkers

Cytokine functional groupCytokineSarcoidosisScleroderma
Innate immunityIL-1β++
IL-6++
IL-8++
TNF-RI++
TNF-RII+++
IFN-α+
IL-12 p40++
IL-15++
Adaptive immunity
 T regulatoryIL-10++
 Th17IL-17++
Chemokines
 Th1 CXCR3 ligandsIP-10++
MIG++
 Th1 CCR5 ligandsMIP-1α++
MIP-1β++
RANTES++
 Th2 CCR2MCP-1++
 Th2 CCR3Eotaxin+#
Growth factorsHGF++
EGF++
ApoptosisDR5++
  • The table profiles serum concentrations of all identified differentially expressed biomarkers in sarcoidosis and scleroderma, classified according to their predominant immune function. Th: T helper cell; IL: interleukin; TNF: tumour necrosis factor; IP: interferon-inducible protein; MIG: monokine induced by interferon-γ; MIP: macrophage inflammatory protein; RANTES: regulated on activation, normal T cell expressed and secreted; MCP: monocyte chemotactic protein; HGF: hepatocyte growth factor; EGF: epidermal growth factor; DR: death receptor. +: median serum concentration was significantly higher than the healthy control population. ++: median serum concentration was significantly higher than the healthy control population and the other disease group; #: in untreated patients only.