Characteristics, clinical manifestations, and pulmonary function tests at diagnosis in patients with combined pulmonary fibrosis and emphysema syndrome
| Variables | |
| Sex male/female n | 38/2 |
| Age yrs | 68.2±8.9 (47.7–82.2) |
| Current/ex/never-smokers n | 2/37/1 |
| Smoking history pack-yrs | 46±23 (17–120) |
| NYHA class I | 0 |
| NYHA class II | 6 (15) |
| NYHA class III | 22 (55) |
| NYHA class IV | 12 (30) |
| 6MWD m | 244±126 (78–689) |
| 6MWT Sp,O2 at end of test | 77±10 (62–96) |
| 6MWT Sp,O2 decrease during test | -15±8 (-30– -1) |
| FVC % pred | 86±18 (46–116) |
| FEV1 % pred | 78±19 (38–114) |
| FEV1/FVC % | 75±18 (29–107) |
| TLC % pred | 84±23 (47–139) |
| RV % pred | 87±47 (41–219) |
| DL,CO % pred | 24±14 (3–52) |
| KCO % pred | 28±16 (4–68) |
| Pa,O2 at rest kPa | 7.5±1.6 (5.2–11.7) |
| Pa,O2 at rest mmHg | 56.2±12.0 (39–84) |
| Pa,CO2 at rest kPa | 4.7±0.6 (3.3–5.9) |
| Pa,CO2 at rest mmHg | 35.2±4.5 (25–44) |
Data are presented as mean±sd (range) or n (%), unless otherwise stated. NYHA: New York Heart Association; 6MWD: 6-min walk distance; 6MWT: 6-min walk test; Sp,O2: peripheral oxygen saturation; FVC: forced vital capacity; % pred: % predicted; FEV1: forced expiratory volume in 1 s; TLC: total lung capacity; RV: residual volume; DL,CO: single-breath diffusing capacity of the lung for carbon monoxide; KCO: single breath transfer factor of the lung for carbon monoxide; Pa,O2: arterial oxygen tension; Pa,CO2: arterial carbon dioxide tension.