Table 1—

Per cent reduction with sildenafil, simvastatin and combination treatment on hypoxia-induced changes on pulmonary artery pressure (Ppa), right ventricular hypertrophy (RVH), vascular remodelling and haematocrit (Hct)

TreatmentPrevention studyTreatment study
PpaRVHRemodellingHctPpaRVHRemodellingHct
Simvastatin15±650±529±522±512±661±326±515±2
Sildenafil44±521±525±350±1035±320±3
Simvastatin and sildenafil64±779±547±519±369±782±350±519±5
  • Data from the prevention study group are presented as per cent reduction after 2 weeks’ hypoxia-induced changes. Data from the treatment study group are presented as per cent reduction after 4 weeks’ hypoxia-induced changes.