Table 1—

Clinical characteristics of the 140BMPR2 mutation carriers genotyped for the CYP1B1 Asn453Ser (453 N/S) polymorphism

AMCsUMCs
Subjects n9248
Females62 (67.4)24 (50.0)
Diagnosis age yrs35.9±13.7NA
Baseline haemodynamic data at diagnosis
 Right atrial pressure mmHg10.9±8.4NA
pa mmHg58.3±13.2NA
 Cardiac index L·min·m−21.87±0.7NA
 Indexed PVR U·m218.3±14.0NA
  • Data are presented as n (%) or mean±sd, unless otherwise stated. AMC: affected mutation carrier; UMC: unaffected mutation carrier; pa: mean pulmonary artery pressure; PVR: pulmonary vascular resistance; NA: not available.