Table 3—

Distribution of CD4 and CD4+Foxp3+ T-regulatory cells

COPDSmokersNonsmokersp-value
Absolute numbers
CD4+
  Sub-epithelial448 (160–1750)200 (120–1260)260 (50–940)0.02
  Follicle4390 (2040–10370)3370 (1410–5640)2900 (1740–7900)0.004
  Cluster4410 (2630–11810)5330 (2100–28850)4080 (1520–6710)ns
CD4+Foxp3+
  Sub-epithelial36 (0–490)64 (0–310)10 (0–250)ns
  Follicle570 (100–1890)310 (5–1280)350 (0–860)0.0007
  Cluster330 (110–4350)560 (110–5910)310 (30–930)ns
Percentage T-regulatory cells
 CD4+Foxp3+
  Sub-epithelial7 (0–28)8 (0–55)2 (0–48)ns
  Follicle16 (3–48)10 (3–35)8 (0–20)0.02
  Cluster8 (3–37)11 (3–20)9 (1–21)ns
  p-value0.0007nsns
  • Data is presented as median (range) for the absolute numbers of positive cells per unit area and as a percentage of the total CD4+ cells that were also Foxp3+. Within each group the absolute CD4 and CD4+Foxp3+ populations were significantly different between areas of interest (p<0.0001). COPD: chronic obstructive pulmonary disease; ns: nonsignificant.