Changes in lung function in healthy nonsmoking, nonfarming controls, smokers and farmers
| ΔVC L LPS | ΔVC L dust | ΔFEV1 L LPS | ΔFEV1 L dust | |||||
| Mean (95% CI) | p-value | Mean (95% CI) | p-value | Mean (95% CI) | p-value | Mean (95% CI) | p-value | |
| Controls | -0.12 (-0.21– -0.04) | 0.008 | -0.22 (-0.32– -0.13) | 0.0004 | -0.10 (-0.18– -0.02) | 0.02 | -0.26 (-0.35– -0.17) | <0.0001 |
| Farmers | -0.01 (-0.13–0.10) | 0.8 | -0.10 (-0.17– -0.03) | 0.01 | -0.05 (-0.18–0.08) | 0.4 | -0.14 (-0.26– -0.03) | 0.02 |
| Smokers | -0.09 (-0.23–0.05) | 0.2 | -0.21 (-0.39– -0.03) | 0.02 | 0.02 (-0.11–0.15) | 0.8 | -0.12 (-0.25–0.003) | 0.06 |
Differences (Δ) between pre-exposure and 7 h after lipopolysaccharide (LPS) challenge and exposure in a pig barn. The influence of LPS and pig barn exposure did not differ significantly between the three groups. CI: confidence interval; VC: vital capacity; FEV1: forced expiratory volume in 1 s.