Table 3—

Risk of an adverse outcome(death or lung transplantation) in relation to risk marker measurements at the onset of intravenous iloprost therapy

Simple modelMultiple model
HR (95% CI)p-valueHR (95% CI)p-value
ra per 1 mmHg increase1.05 (1.0–1.09)0.042
Cardiac index per 0.5 L·min−1·m2 decrease1.5 (1.06–2.13)0.02
PVR per 100 dyn·sec·cm−5 increase1.02 (0.99–1.05)0.11
Sv,O2 per 5% decrease1.3 (1.13–1.5)<0.0011.1 (1.01–1.2)0.003
pa per 5 mmHg increase1.03 (0.95–1.1)0.49
6MWD per 20 m decrease#1.0 (0.99–1.01)0.6
NYHA class1.7 (1.2–2.8)0.046
  • Estimated hazard ratios (HR), 95% confidence intervals (CI), and p-values were calculated by simple and stepwise forward Cox regression analyses. HRs refer to the indicated scales in these variables. ra: mean right atrial pressure; PVR: pulmonary vascular resistance; Sv,O2: mixed venous oxygen saturation; pa: mean pulmonary artery pressure; 6MWD: 6-min walk distance; NYHA: New York Heart Association. #: 6MWD data were available for only 42 patients; : NYHA data were available for only 73 patients.