Table 3—

Odds ratios for risk of death associated with formoterol treatment at randomisation

All deathsAsthma deaths
Simple contingency two-by-two table method
 Formoterol deaths#25/27821 (0.09)7/27821 (0.03)
 Comparator deaths#17/21506 (0.08)2/21506 (0.01)
 OR (95% CI)1.1 (0.6–2.2)2.7 (0.5–26.7)
Peto’s method
 Studies with data n125
 OR (95% CI)
  Fixed effects1.2 (0.6–2.2)2.8 (0.7–10.4)
  Random effects1.2 (0.6–2.2)2.8 (0.7–10.4)
Bayesian method
 Relative risk (95% credible interval)
  Vague prior1.1 (0.5–2.5)2.0 (0.4–10.1)
  Informative prior1.3 (0.8–1.9)3.2 (1.3–8.7)
  • #: presented as deaths/total subjects (%). : the prior used for total deaths was the confidence interval for the odds ratio for all deaths of 0.8–2.1 from SMART (Salmeterol Multicentre Asthma Research Trial); for asthma deaths the confidence interval 1.2–15.3 was used.