Table 2—

Other causes of death

First author [ref.]Daily dose of randomised treatmentConcomitant LABA therapyICS-exposed patientCause of death
Pauwels 26Formoterol 4.5 μg p.r.n.SalmeterolYesCardiac failure, myocardial infarction
Pauwels 26Formoterol 4.5 μg p.r.n.FormoterolYesCardiopulmonary failure
Pauwels 26Formoterol 4.5 μg p.r.n.NoMyocardial infarction
Pauwels 26Formoterol 4.5 μg p.r.n.YesMyocardial ischaemia
Pauwels 26Formoterol 4.5 μg p.r.n.SalmeterolYesMyocardial infarction, cardiac failure, intestinal ischaemia
Pauwels 26Formoterol 4.5 μg p.r.n.SalmeterolYesMyocardial infarction
Pauwels 26Formoterol 4.5 μg p.r.n.UnknownOvarian cancer
Pauwels 26Formoterol 4.5 μg p.r.n.UnknownBrain neoplasm
Pauwels 26Formoterol 4.5 μg p.r.n.UnknownCerebrovascular accident
Pauwels 26Formoterol 4.5 μg p.r.n.UnknownCarbon monoxide poisoning
O'Byrne 28Formoterol/budesonide 9/160 μgYesSudden death
Pauwels 30Formoterol 18 μg plus budesonide 640 μgYesSuicide
Brambilla 35Formoterol 24 μg plus salbutamol 100 μg p.r.n.YesCerebrovascular accident
Brambilla 35Formoterol 24 μg plus salbutamol 100 μg p.r.n.YesBrain metastasis secondary to lung carcinoma
Buhl 36Formoterol/budesonide 9/320 μgYesCardiac arrest
Jenkins 37Formoterol/budesonide 36/1280 μgYesPulmonary embolism
Scicchitano 38Formoterol/budesonide 9/320 μg plus formoterol/budesonide 4.5/160 μg p.r.n.YesMetastases to peritoneum
Zetterström 39Formoterol/budesonide 18/640 μgYesSuicide
Pauwels 26Salbutamol 200 μg p.r.n.NoAortic stenosis, tracheobronchitis
Pauwels 26Salbutamol 200 μg p.r.n.NoSudden cardiac death
Pauwels 26Salbutamol 200 μg p.r.n.FormoterolYesCardiac arrest
Pauwels 26Salbutamol 200 μg p.r.n.YesCardiac failure, ovarian cancer
Pauwels 26Salbutamol 200 μg p.r.n.NoMyocardial infarction
Pauwels 26Salbutamol 200 μg p.r.n.SalmeterolYesMyocardial infarction
Pauwels 26Salbutamol 200 μg p.r.n.SalmeterolYesMyocardial infarction
Pauwels 26Salbutamol 200 μg p.r.n.UnknownHepatorenal syndrome, hepatic cirrhosis
Pauwels 26Salbutamol 200 μg p.r.n.UnknownCerebrovascular accident
O'Byrne 28Budesonide 640 μg plus terbutaline 400 μg p.r.n.YesUnknown
Price 31Budesonide 800 μgYesCerebral haemorrhage
Pleskow 32Salbutamol 720 μgUnknownAcute pancreatitis
Brambilla 35Salbutamol 100 μg p.r.n.YesCardio-respiratory deficiency
Scicchitano 38Budesonide 640 μg plus terbutaline 400 μg p.r.n.YesMyocardial infarction
Scicchitano 38Budesonide 640 μg plus terbutaline 400 μg p.r.n.YesHypertrophic cardiomyopathy
  • LABA: long-acting β-agonist; ICS: inhaled corticosteroids.