Table 1—

Asthma-related deaths

First author [ref.]Daily dose of randomised treatmentConcomitant LABA therapyICS-exposed patientCause of death
Pauwels 26Formoterol 4.5 μg p.r.n.SalmeterolYesAsthma
Pauwels 26Formoterol 4.5 μg p.r.n.YesAsthma
Pauwels 26Formoterol 4.5 μg p.r.n.NoAsthma
O'Byrne 28Formoterol/budesonide 9/160 μg plus terbutaline 400 μg p.r.n.YesAsthma
O'Byrne 29Formoterol 9 μg plus budesonide 160 μgYesStatus asthmaticus
Pleskow 32Formoterol 48 μgNoAsthma
von Berg 33Formoterol 18 μgYesRespiratory failure
Pauwels 26Salbutamol 200 μg p.r.n.NoAsthma
Pauwels 26Salbutamol 200 μg p.r.n.YesAsthma
  • LABA: long-acting β-agonist; ICS: inhaled corticosteroids.