Table 5—

Regular preventative therapy for episodic pre-school viral wheeze

MedicineQuality of evidenceRecommendationComment
Inhaled corticosteroidsNo effect on clinically relevant outcomes (moderate)Regular inhaled corticosteroids should probably not be usedLow number of pre-school children evaluated
Inhaled LABAInsufficient evidence in this phenotype (very low)Inhaled LABA should not be usedNo published studies in this phenotype
MontelukastSome mild beneficial effects on clinical outcomes (moderate)Montelukast should probably be used on case-by-case basisOnly one RCT
  • LABA: long-acting β2-agonist; RCT: randomised controlled trial.