Table 2—

Cytokines in lung tissue from offspring

Cytokine pg·mL−1NSMSMLinear regression analysis
PBSHDMPBSHDMHDM effectSM effect
IL-2229 (195–309)306 (239–414)*224 (187–285)292 (242–330)*p = 0.002p = 0.265
IL-42.1 (1.7–2.7)9.1 (2.9–26.9)***1.9 (1.7–1.9)7.0 (6.0–21.4)***p<0.001p = 0.986
IL-512.5 (9.9–17.8)17.8 (10.6–26.7)8.6 (8.6–14.2)13.9 (7.3–28.4)p = 0.028p = 0.072
IL-6112 (96–124)149 (109–286)*103 (83–118)191 (126–354)**p = 0.002p = 0.318
IL-101399 (1109–1513)868 (715–1245)**1276 (1028–1443)952 (713–1239)p<0.001p = 0.811
IL-13542 (500–613)542 (472–724)500 (444–549)556 (528–725)**p = 0.014p = 0.759
IL-1712.4 (10.9–14.5)1018 (83.9–3144)***11.7 (10.9–12.4)1096 (160–2068)***p<0.001p = 0.925
IFN-γ95.3 (69.8–124.6)62.5 (28.3–96.6)72.7 (50.0–102.1)64.2 (19.1–83.8)p = 0.027p = 0.302
TNF14.2 (11.8–16.2)15.4 (11.8–19.3)12.2 (10.7–13.7)15.7 (13.7–19.2)***p = 0.012p = 0.415
Eotaxin1588 (1376–1803)2222 (1678–2475)**1450 (1313–1637)1809 (1527–2417)*p<0.001p = 0.319
  • Data are presented as median (interquartile range), unless otherwise stated. NSM: nonsmoking mother; SM: smoking mother; HDM: house dust mite; IL: interleukin; IFN: interferon; TNF: tumour necrosis factor. *: p<0.05; **: p<0.01; ***: p<0.001 from subgroup analysis (HDM versus PBS group).