Table 1—

Treatment-emergent adverse events and possible relationship to study drug

	iNO	Riociguat
		Incremental dose		Single dose
		0.5+1+1 mg	1+2+2 mg	1 mg	2.5 mg
Subjects n	19	2	2	5	10
Adverse events^#	0 (0)	1 (50)	1 (50)	1 (20)	1 (10)
Renal and urinary disorders		Micturition urgency^¶	Urinary retention^¶
Vascular disorders		Hot flush⁺
Nervous system disorders				Dizziness⁺
Respiratory, thoracic and mediastinal disorders				Cough^¶	Nasal congestion⁺

Data are presented as n (%), unless otherwise stated. iNO: inhaled nitric oxide. ^#: all adverse events were mild in severity; ^¶: not drug related; ⁺: at least possibly drug related.