Table 3—

Two-step evolution of microRNAs in lung squamous carcinogenesis

Differentially expressed microRNAsGroups compared
0 and 10 and 20 and 31 and 22 and 32 and 3A3A and 3BCIS and 3B
Total number619191630152010
Downregulated5 (83)16 (84)14 (74)14 (87.5)17 (57)3 (20)8 (40)5 (50)
Upregulated1 (17)3 (16)5 (26)4 (12.5)13 (43)12 (80)12 (60)5 (50)
  • Data are presented as n or n (%). CIS: carcinoma in situ. Two successive waves were observed in microRNA expression profiles during lung squamous carcinogenesis: first, a downregulation and, secondly, an upregulation of microRNAs. In the first four comparisons of microRNA profiles, between groups 0 and 1, 0 and 2, 0 and 3, and 1 and 2, the large majority of microRNAs were downregulated. In the later four comparisons, the proportion of downregulated microRNAs decreased and that of upregulated microRNAs increased, with ≥50% being upregulated for comparisons between groups 2 and 3A, 3A and 3B, and CIS and 3B.