Table 2—

Statistically significantly evolving microRNAs during lung carcinogenesis

MicroRNA nameGroups compared
0 and 10 and 20 and 31 and 22 and 32 and 3A3A and 3BCIS and 3B
hsa-miR-1Down 5.88Down 10.00
hsa-miR-7Up 4.11Up 3.96
hsa-miR-9Down 11.11Up 17.89#Up 15.97#Up 3.05
hsa-miR-9*Up 2.49Up 5.66
hsa-miR-10bDown 3.03Up 2.95
hsa-miR-15aDown 5.00Down 6.67Down 3.45
hsa-miR-17-5pUp 2.15
hsa-miR-32Down 6.67Down 5.88Down 4.17
hsa-miR-34aDown 5.00
hsa-miR-34cDown 6.67Down 14.29#Down 25.00#Down 2.50
hsa-miR-99aDown 1.96Down 1.89
hsa-miR-101Down 5.56Down 3.57#
hsa-miR-106bUp 2.06Up 2.36
hsa-miR-132Up 2.18
hsa-miR-133aDown 5.88
hsa-miR-134Down 2.70
hsa-miR-135aDown 4.17Down 4.00#Down 4.00
hsa-miR-139Down 2.27Down 5.26Down 5.88#
hsa-miR-142-3pDown 2.94Down 5.56Up 2.60Up 2.50Up 2.51Up 2.24
hsa-miR-142-5pDown 2.38Up 2.86Up 3.36
hsa-miR-143Down 3.85
hsa-miR-145Down 2.70
has-miR-183Up 2.66
hsa-miR-190Down 4.76
hsa-miR-193aDown 8.33#
hsa-miR-193bDown 4.17Up 5.66
hsa-miR-196aUp 16.95#Up 25.69#Up 28.29#
hsa-miR-196bUp 10.48Up 10.80#Up 10.78#
hsa-miR-199aUp 8.77#Up 20.87
hsa-miR-203Up 5.26#Up 4.89Up 5.79#
hsa-miR-204Down 11.11Down 16.67
hsa-miR-206Up 3.86Down 2.33
hsa-miR-213Down 3.57
hsa-miR-214Down 2.00#Up 2.35Up 2.67
hsa-miR-216Down 3.33Down 2.63Down 2.44
hsa-miR-218Down 5.56Down 3.57
hsa-miR-224Up 2.58Up 1.63#Up 3.79#Up 1.63
hsa-miR-301Down 3.57Up 2.47
hsa-miR-324-5pDown 10.00
hsa-miR-338Up 5.07
hsa-miR-361Down 6.25Down 4.76
hsa-miR-362Up 2.75Up 3.36
hsa-miR-374Down 1.49
hsa-miR-375Down 6.25Down 7.14#Down 11.11
hsa-miR-382Down 2.44
hsa-miR-410Down 2.63
hsa-miR-411Down 4.76
hsa-miR-422bDown 4.76Down 4.76Down 4.17
hsa-miR-432Up 3.46
hsa-miR-449Down 3.33Down 5.56Down 5.56
hsa-miR-449bDown 11.11
hsa-miR-451Down 8.33
hsa-miR-452Up 14.81#Up 6.47#Up 6.10#
hsa-miR-486Down 10.00
hsa-miR-487bUp 8.19Up 19.03#
hsa-miR-492Down 2.5
hsa-miR-518dDown 2.63
hsa-miR-521Down 1.56
hsa-miR-545Down 2.78
hsa-miR-565Down 1.67Down 2.08
hsa-miR-572Down 3.45Down 3.85
hsa-miR-597Up 5.43
hsa-miR-615Up 9.74
hsa-miR-622Down 6.25
hsa-miR-639Down 2.86
has-miR-642Down 5.00#Down 12.50Down 2.17Down 3.33Down 6.67
hsa-miR-646Down 5.00
hsa-miR-650Up 4.97
hsa-miR-659Up 4.83Down 3.70Up 6.81
  • Data are presented as fold changes. CIS: carcinoma in situ; down: downregulated; up: upregulated. All the microRNAs found differentially expressed in at least one of the eight comparisons are shown (t-test p<0.05). #: microRNAs remaining statistically differentially expressed in a specific comparison after correction for multiple testing (CMT) at Bonferroni corrected p-value <0.05. In the first comparison (group 0 versus group 1), no microRNA expression difference remained statistically significant after CMT, whereas, in the seven other comparisons, the numbers of microRNAs with differential expression remaining statistically significant after CMT were three, six, four, five, four, one and two (from left to right).