Table 3—

Summary of studies examining the clinical effectiveness of macrolide therapy in chronic obstructive pulmonary disease

First author [ref.]Study designDrug regimenAdults/ children nLength of studyBenefit?Adverse effects (treatment arm)
Banerjee 38Block, randomised, prospective, double-blind, placebo-controlledClarithromycin 500 mg once daily673/12 monthsHealth status unchanged; exacerbation rate unchanged; sputum bacterial numbers unchangedOne withdrawal due to gastrointestinal upset
Wilkinson 39Randomised, double-blind, placebo-controlledErythromycin 250 mg twice daily1091 yr↓Incidence of exacerbationsNot presented