Table 4—

Elevated bronchoalveolar lavage(BAL) fluid matrix metalloproteinase (MMP) and protein permeability in patients who died early during follow-up

DiedSurvivedp-value
Subjects n812
MMP-1 pg·mL−113 (13–56)16.6 (13–76.8)0.79
MMP-2 pg·mL−174 ( 91–813)74 (74–1092)0.75
MMP-3 pg·mL−172 (28–91)8 (3–28.5)0.0081
MMP-7 pg·mL−110012 (4650–30399)3187 (88–10105)0.16
MMP-8 pg·mL−133705 (15276–41451)1225 (373–6810)0.0015
MMP-9 pg·mL−1115834 (49055–167675)3331 (877–15086)0.0015
MMP-12 pg·mL−118180.96
BAL protein mg·mL−10.380.230.3415
PPI0.01594 (0.008–0.044)0.00434 (0.0033–0.0482)0.04
Plasma protein mg·mL−1921260.458
TIMP-1 pg·mL−115185 (7674–23593)2245 (1070–7063)0.01
TIMP-2 pg·mL−11448 (765–2102)488 (365–1693)0.02
  • Data are presented as median (interquartile range) or median, unless otherwise stated. PPI: protein permeability index; TIMP: tissue inhibitor of metalloproteinase.