Table 5—

Genotype–sex interactions for acute respiratory distress syndrome (ARDS) risk

Genotype–sex interactionAll subjects#Age <65 yrsAge ≥65 yrs+
OR (95% CI)§p-valueƒOR (95% CI)§p-valueƒOR (95% CI)§p-valueƒ
rs4444903·sex2.01 (1.18–3.43)0.010##2.50 (1.18–5.33)0.017##1.55 (0.72–3.33)0.261
rs2298991·sex2.02 (1.18–3.43)0.010##2.67 (1.26–5.69)0.011##1.44 (0.67–3.07)0.350
rs11568893·sex0.99 (0.52–1.89)0.9731.20 (0.49–2.96)0.6880.69 (0.26–1.85)0.464
rs7692976·sex2.07 (1.22–3.54)0.007##3.08 (1.45–6.57)0.004##1.32 (0.62–2.82)0.473
rs4698803·sex0.64 (0.37–1.09)0.1000.68 (0.32–1.48)0.3360.61 (0.28–1.30)0.200
rs6533485·sex1.96 (1.11–3.46)0.021##2.46 (1.09–5.56)0.031##1.46 (0.66–3.26)0.353

  • OR: odds ratio; CI: confidence interval. Females with wildtype homozygote of each single nucleotide polymorphism were used as a reference. #: n = 1,468; : n = 736; +: n = 732; §: for interaction in multivariate logistic regression models, adjusted for age, sex, Acute Physiology and Chronic Health Evaluation (APACHE) III score, all risk factors for ARDS (table 1⇑), diabetes, liver cirrhosis/failure and alcohol abuse. APACHE III score was revised to remove age from the score, to avoid colinearity. ƒ: for interaction. ##: false discovery rate adjusted p-value <0.05.