Table 2—

Summary of seven single nucleotide polymorphisms(SNPs)

SNP	Allele	Location	Position^#	Minor allele frequency (ARDS/controls)			HWE p-value^¶
SNP	Allele	Location	Position^#	All subjects	Male	Female	HWE p-value^¶
rs4444903	A>G	5′ UTR	111053559	0.436/0.416	0.441/0.393	0.429/0.453	0.140
rs2298991	T>G	Intron 11	111111461	0.433/0.421	0.439/0.400	0.424/0.453	0.169
rs11568993	C>T	Exon 13	111116764	0.096/0.095	0.083/0.094	0.115/0.097	0.592
rs6850557	G>A	Intron 18	111130464	0.359/0.347	0.364/0.333	0.353/0.367	<0.001⁺
rs7692976	A>G	Intron 18	111131016	0.440/0.417	0.455/0.399^§	0.418/0.447	0.134
rs4698803	T>A	Exon 19	111133876	0.168/0.192	0.152/0.199^§	0.191/0.181	0.026
rs6533485	G>C	Intron 22	111147012	0.499/0.491	0.504/0.481	0.509/0.494	0.630

ARDS: acute respiratory distress syndrome; HWE: Hardy–Weinberg equilibrium; UTR: untranslated region. ^#: chromosome positions based on the National Center for Biotechnology Information Build 36; ^¶: Chi-squared test for deviation from the HWE equilibrium in all controls; ⁺: false discovery rate adjusted p-value <0.05;^§: p-value by Chi-squared test <0.05.