Ventilator settings, gas exchange parameters, and requirements of vasopressors and analgesics before initiation, after initiation and on the second and fourth day of pumpless extracorporeal lung assist(pECLA) therapy
| Parameter | Pre-pECLA | 12 h pECLA therapy | Day 2 pECLA therapy | Day 4 pECLA therapy |
| Inspiratory plateau pressure cmH2O | 32.4 (29.8–35.9) | 28.6 (28.8–31.3) | 27.1 (26.3–32.3) | 27.6 (25.6–31.0) |
| PEEP cmH2O | 14.0 (12.3–16.5) | 15.0 (12.8–16.5) | 15.5 (12.8–16.8) | 14.5(10.3–15.8) |
| Minute ventilation L·min−1 | 8.4 (7.2–10.0) | 6.9(4.1–7.2) | 6.0 (4.6–6.9) | 5.3 (3.2–7.5) |
| Respiratory rate L·min−1 | 23 (18–33) | 19(14–29) | 22 (16–32) | 22 (19–29) |
| Tidal volume mL per kg PBW | 5.1 (4.1–6.4) | 3.9 (2.8–4.3) | 3.3 (2.2–3.9) | 2.8 (2.4–3.1) |
| Assisted spontaneous breathing# % | 7.2 (0–23.1) | 17.4 (0–38.3) | 27.7 (2.9–58.2) | 40.7 (7.4–71.9) |
| pH | 7.24 (7.10–7.37) | 7.41 (7.23–7.46) | 7.37 (7.32–7.43) | 7.38 (7.29–7.43) |
| Pa,CO2 mmHg | 73.6 (67.1–78.5) | 53.4 (37.4–59.8) | 50.3 (49.1–57.8) | 54.0 (53.3–65.3) |
| Pa,O2/FI,O2 mmHg | 141 (83–266) | 166 (137–232) | 147 (119–224) | 201 (116–315) |
| Norepinephrine μg·kg−1·min−1 | 0.47 (0.12–0.76) | 0.30 (0.08–0.48) | 0.18 (0.06–0.22) | 0.09 (0.07–0.19) |
| Fentanyl μg·kg−1·h−1 | 12.1 (7.2–25.9) | 12.1 (7.2–25.1) | 10.4 (3.6–19.9) | 10.0 (3.5–19.9) |
Data are presented as median (interquartile range). PEEP: positive end-expiratory pressure; PBW: predicted body weight; Pa,CO2: arterial carbon dioxide tension; Pa,O2: arterial oxygen tension; FI,O2: inspiratory oxygen fraction. #: proportion of minute volume that was assisted spontaneous ventilation. 1 mmHg = 1.36 cmH2O = 0.133 kPa.