Multivariable logistic regression analysis# for probability of any exacerbation¶
| SNP | Unadjusted OR (95% CI) | p-value | Adjusted OR (95% CI) | p-value |
| rs2118177 | 0.8 (0.6–1.1) | 0.1 | 0.8 (0.6–1.1) | 0.2 |
| rs2304566 | 0.8 (0.6–1.1) | 0.1 | 0.8 (0.5–1.1) | 0.1 |
| rs1130866 | 0.8 (0.6–1.1) | 0.1 | 0.8 (0.6–1.1) | 0.1 |
| rs2077079 | 1.2 (0.9–1.7) | 0.2 | 1.2 (0.9–1.6) | 0.3 |
| rs3024791 | 0.6 (0.4–0.9) | 0.008 | 0.6 (0.4–0.9) | 0.007 |
SNP: single nucleotide polymorphism; OR: odds ratio; CI: confidence interval. #: adjusted for age, sex, smoking history pack-yrs, forced expiratory volume in one second % predicted and treatment; ¶: 216 National Emphysema Treatment Trial subjects with at least one exacerbation and 575 total chronic obstructive pulmonary disease exacerbations.