Semiquantative evaluation of cytokines
| Cytokine | Cell culture | ||||
| A549 | THP-1 | HMC-1 | Triculture | Triculture + EAHY926 | |
| G-CSF | 4.4 | 22.5 | |||
| GRO-α | 0.25 | 0.5 | |||
| I-309 | 0.35 | 0.07 | |||
| sICAM | 2 | 2.7 | 1.5 | ||
| IL-1β | 3.5 | 2.6 | |||
| IL-6 | 4.4 | ||||
| IL-8 | 0.27 | 0.23 | |||
| IL-23 | 0.3 | ||||
| IL-32 | 0.11 | ||||
| MCP-1 | 0.05 | 0.04 | |||
| MIP-1α | 0.5 | 8.4 | 65 | ||
| MIP-1β | 1.5 | 13.4 | |||
| RANTES | 1.5 | 0.32 | 0.1 | ||
| TNF-α | 90 | ||||
Data are presented as fold changes after exposure to particles with a 50% cut-off aerodynamic diameter of 10 μm (100 µg·cm−2) compared with unexposed cultures, as calculated from the semiquantitative array membranes (fig. 2⇑). Cytokines with a variation >50% in relation to the control were considered relevant and are expressed in this table. A549: epithelial type-II pneumocytes; THP-1: macrophage-like cells; HMC-1: mast cells; EAHY926: endothelial cells; G-CSF: granulocyte colony-stimulating factor; GRO: growth-related oncogene; sICAM: soluble intercellular adhesion molecule; IL: interleukin; MCP: monocyte chemotactic protein; MIP: macrophage inflammatory protein; TNF: tumour necrosis factor.