Clinical characteristics of study participants stratified in quintiles of fibronectin(F) to C-reactive protein (CRP) ratio
| F/CRP ratio quintile | Total | p-value | |||||
| 1 | 2 | 3 | 4 | 5 | |||
| Subjects n | 957 | 958 | 957 | 958 | 957 | ||
| F/CRP ratio | 20.57±9.16 | 55.25±11.46 | 108.91±21.28 | 218.12±45.97 | 802.39±1069.96 | 241.01±558.99 | <0.001 |
| Fibronectin μg·mL−1 | 315.40±210.77 | 366.01±212.21 | 404.48±445.54 | 416.81±291.30 | 441.18±522.02 | 388.78±361.75 | <0.001 |
| CRP μg·mL−1 | 22.24±36.55 | 6.96±4.52 | 3.82±3.89 | 2.01±1.52 | 0.77±0.87 | 7.16±18.32 | <0.001 |
| Age yrs | 54.71±6.34 | 53.9±6.59 | 53.67±6.79 | 53.07±6.82 | 52.06±7.02 | 53.50±6.78 | <0.001 |
| Male | 511 (53) | 612 (64) | 635 (66) | 632 (66) | 623 (65) | 3036 (63) | <0.001 |
| White | 899 (94) | 917 (96) | 929 (97) | 930 (97) | 931 (97) | 4644 (96) | 0.001 |
| Smoking history pack-yrs | 41.81±17.77 | 42.12±20.07 | 40.02±18.27 | 39.2±18.31 | 37.44±18.36 | 40.15±18.71 | <0.001 |
| BMI kg·m−2 | 26.19±4.22 | 26.36±3.86 | 25.67±3.87 | 25.12±3.61 | 24.46±3.62 | 25.56±3.91 | <0.001 |
| FEV1 L | 2.33±0.6 | 2.5±0.64 | 2.56±0.66 | 2.62±0.67 | 2.68±0.7 | 2.54±0.67 | <0.001 |
| FEV1 % pred | 69.05±11.94 | 70.25±11.82 | 70.82±12.97 | 72.21±12.34 | 72.66±12.64 | 70.99±12.41 | <0.001 |
| Intermittent smokers | 259 (27) | 255 (27) | 276 (29) | 273 (28) | 291 (30) | 1363 (28) | 0.739 |
| Continuous smokers | 582 (61) | 536 (56) | 518 (54) | 478 (50) | 470 (49) | 2607 (54) | <0.001 |
| Daily sputum | 311 (32) | 281 (29) | 306 (32) | 297 (31) | 274 (29) | 1477 (31) | 0.580 |
| Daily cough | 365 (38) | 319 (33) | 342 (36) | 334 (35) | 326 (34) | 1697 (35) | 0.416 |
| Diastolic BP mmHg | 78.1±9.37 | 78.48±8.77 | 78.59±9.74 | 77.94±8.89 | 77.25±9.54 | 78.08±9.27 | 0.029 |
| Systolic BP mmHg | 123.5±15.42 | 123.35±14.26 | 122.4±15.84 | 121.42±13.96 | 119.74±14.7 | 122.10±14.91 | <0.001 |
| Theophylline | 27 (2.82) | 25 (2.61) | 17 (1.78) | 14 (1.46) | 15 (1.57) | 98 (2.03) | 0.218 |
| Inhaled corticosteroids | 15 (1.57) | 9 (0.94) | 19 (1.99) | 7 (0.73) | 12 (1.25) | 62 (12.8) | 0.226 |
| Beta-blockers | 41 (4.28) | 40 (4.18) | 36 (3.76) | 22 (2.30) | 27 (2.82) | 167 (3.46) | 0.136 |
| Diabetics | 29 (3.03) | 19 (1.98) | 16 (1.67) | 14 (1.46) | 10 (1.05) | 88 (1.82) | 0.037 |
Data are presented as mean±sd or n (%), unless otherwise stated. BMI: body mass index; FEV1: forced expiratory volume in one second; % pred: % predicted; BP: blood pressure.