Table 3—

Quantitative computed tomography measurements at baseline and after treatment

Baseline1 month3 months6 months
Subjects n57343416
Total lung
 Volume mL6840±13756737±13836852±14566429±1605
 Difference mL-54±495-45±34739±305
 % change-0.6±7.8-0.9±5.40.6±5.3
Upper lobe
 Volume mL3419±8723058±845#3165±976#3025±1212***
 Difference mL-328±511#-319±427#-335±444***
 % change-9.3±14.1-9.5±12.2-10.2±12.7
Nonupper lobe
 Volume mL3421± 8673679±869#3687±982#3404±1025#
 Difference mL274±419#274±334#374±387#
 % change9.2±13.98.4±10.211.6±11.6
Total lung
 Mass g728±183714±165715±181680±195
 Difference g2±126-15±139-62±108
 % change1.2±15.3-0.6±16.6−7.3±13.0
Upper lobe
 Mass g301±90259±75**266±111***238±99***
 Difference g-36±67**-37±72***-71±63***
 % change-10.5±19.3-12.3±19.5-22.6±15.9
Nonupper lobe
 Mass g427±111455±105449±86442±113
 Difference g37±75*22±969±71
 % change10.2±16.88.0±17.53.0±15.0
Total lung
 Density g·mL−10.108±0.0260.107±0.0200.105±0.0190.107±0.021
 Difference g·mL−10.000±0.026-0.001±0.020-0.012±0.025
 % change2.8±19.20.5±17.2-7.2±16.0
Upper lobe
 Density g·mL−10.090±0.0240.087±0.0200.084±0.0220.080±0.022
 Difference g·mL−1-0.003±0.028-0.003±0.019-0.016±0.028*
 % change1.2±27.3-1.9±22.5-12.1±22.4
Nonupper lobe
 Density g·mL−10.129±0.0370.126±0.0230.128±0.0350.136±0.040
 Difference g·mL−1-0.002±0.027-0.002±0.028-0.013±0.024
 % change1.8±16.10.0±16.2-7.3±12.8

  • Data are presented as mean±sd, unless otherwise stated. #: p<0.0001. *: p<0.05; **: p<0.01; ***: p<0.001.