Table 7—

Pooled summary estimates for isoniazid resistance

SubgroupPooled sensitivityPooled specificityPooled LR+Pooled LR-Pooled DOR
All isoniazid studies#84.3 (76.6–89.8)99.5 (97.5–99.9)190.6 (33.4–1086.3)0.16 (0.10–0.24)1210.8 (175.3–8361.5)
Only MTBDRplus assays88.7 (82.4–92.8)99.2 (95.4–99.8)112.6 (18.7–677.7)0.11 (0.07–0.18)986.8 (133.6–7285.9)
Only clinical specimens+84.5 (72.1–92.0)99.2 (96.4–99.8)110.1 (22.3–542.3)0.15 (0.08–0.29)706.6 (97.7–5110.8)
  • Data are presented as % (confidence interval). MTBDRplus is manufactured by Hain LifeScience GmbH (Nehren, Germany). LR+: positive likelihood ratio; LR-: negative likelihood ratio; DOR: diagnostic odds ratio. #: number of comparisons was 15; : number of comparisons was 5; +: number of comparisons was 10.