Subgroup | Pooled sensitivity | Pooled specificity | Pooled LR+ | Pooled LR- | Pooled DOR |

All isoniazid studies^{#} | 84.3 (76.6–89.8) | 99.5 (97.5–99.9) | 190.6 (33.4–1086.3) | 0.16 (0.10–0.24) | 1210.8 (175.3–8361.5) |

Only MTBDRplus assays^{¶} | 88.7 (82.4–92.8) | 99.2 (95.4–99.8) | 112.6 (18.7–677.7) | 0.11 (0.07–0.18) | 986.8 (133.6–7285.9) |

Only clinical specimens^{+} | 84.5 (72.1–92.0) | 99.2 (96.4–99.8) | 110.1 (22.3–542.3) | 0.15 (0.08–0.29) | 706.6 (97.7–5110.8) |

Data are presented as % (confidence interval). MTBDRplus is manufactured by Hain LifeScience GmbH (Nehren, Germany). LR+: positive likelihood ratio; LR-: negative likelihood ratio; DOR: diagnostic odds ratio.

^{#}: number of comparisons was 15;^{¶}: number of comparisons was 5;^{+}: number of comparisons was 10.