Table 5—

Outcome at the end of initial therapy, according to type of drug

Initial therapy	Success rate^#	Adjusted analysis^¶
Initial therapy	Success rate^#	OR⁺	95% CI	p-value^§
Ceftriaxone, cefotaxime or cefepime alone	310/452 (68.6)
Amoxycillin/clavulanate or ampicillin/sulbactam alone	268/378 (70.9)	0.82	0.58–1.16	0.25
Levofloxacin alone	287/363 (79.1)	0.65	0.45–0.95	0.026
Other noncompliant monotherapies	309/428 (72.2)	0.97	0.69–1.35	0.85
Ceftriaxone, cefotaxime or cefepime plus macrolide	253/330 (76.7)	0.72	0.49–1.05	0.084
Amoxycillin/clavulanate or ampicillin/sulbactam plus macrolide	168/229 (73.4)	0.70	0.46–1.07	0.093
Levofloxacin plus antipneumococcal β-lactam^ƒ	123/156 (78.8)	0.66	0.40–1.08	0.097
Noncompliant combinations	325/463 (70.2)	0.98	0.71–1.36	0.90

OR: odds ratio; CI: confidence interval. ^#: successes/total patients on given therapy (%); ^¶: multiple logistic regression model including initial therapy, study phase, Fine score (as a numerical variable on a 10-point scale), antibiotic treatment in the previous 2 weeks (yes or no) and study centre (as a random effect); ⁺: for failure with each therapy versus ceftriaxone, cefotaxime or cefepime alone; ^§: Wald Chi-squared test; ^ƒ: ceftriaxone, cefotaxime, cefepime, amoxicillin/clavulanate or equivalent penicillin.