Genotype frequencies for the nicotinic acetylcholine receptorα5 subunit single nucleotide polymorphism (rs16969968) across all cohorts stratified by chronic obstructive pulmonary disease (COPD) and lung cancer (LC)
| Subjects n | GG | GA | AA | OR (95% CI)# | p-value# | |
| Cohorts stratified by COPD | ||||||
| No COPD | 643 | 306 (48) | 274 (43) | 63 (10) | ||
| COPD | 706 | 252 (36) | 344 (49) | 110 (16) | 1.7 (1.2–2.4) | 0.002 |
| Cohorts stratified by LC | ||||||
| No LC¶ | 920 | 391 (43) | 424 (46) | 105 (11) | ||
| LC+ | 437 | 170 (39) | 199 (46) | 68 (16) | 1.4 (1.0–2.0) | 0.03 |
Data are presented as n (%), unless otherwise stated. OR: odds ratio; 95% CI: 95% confidence interval. #: AA versus GA/GG (Mantel–Haenszel); ¶: 48% with no LC have COPD; +: 60% with LC have COPD.