Genotype frequencies for the nicotinic acetylcholine receptorα5 subunit single nucleotide polymorphism (rs16969968) in chronic obstructive pulmonary disease (COPD) and lung cancer (LC) cohorts compared with smoking controls
| Subjects n | Call rate | GG | GA | AA | OR (95% CI)# | p-value# | |
| Primary cohorts | |||||||
| Controls | 475 | 97 | 225 (47) | 205 (43) | 45 (9) | ||
| COPD | 445 | 97 | 166 (37) | 219 (49) | 60 (14) | 1.5 (1.0–2.3)# | 0.06 |
| LC | 437 | 96 | 170 (39) | 199 (46) | 68 (16) | 1.8 (1.2–2.7) | 0.005 |
| Subgroup analyses | |||||||
| COPD and LC+COPD | 706 | 252 (36) | 344 (49) | 110 (16) | 1.8 (1.2–2.6) | 0.002 | |
| LC+COPD¶ | 261 | 86 (33) | 125 (48) | 50 (19) | 2.3 (1.4–3.6) | 0.0002 | |
| LC only | 168 | 81 (48) | 69 (41) | 18 (11) | 1.2 (0.6–2.1.) | 0.64 |
Data are presented as % or n (%), unless otherwise stated. OR: odds ratio; 95% CI: 95% confidence interval. #: AA versus GA/GG compared with matched smoking controls (Mantel–Haenszel); ¶: AA versus GA/GG compared with COPD and lung cancer alone (OR 2.0, 95% CI 1.1–3.7; p = 0.02).