Univariable and multivariable analyses for isoniazid resistance among new tuberculosis cases in England and Wales, UK, 1999–2005
| Case characteristic | Resistance | Univariable analysis | Multivariable analysis | ||||
| OR | 95% CI | p-value | AOR | 95% CI | p-value | ||
| HIV status | 0.186 | ||||||
| Negative | 1108/16974 (6.5) | 1 | 1 | 0.895 | |||
| Positive | 87/1156 (7.5) | 1.17 | 0.93–1.46 | 1.02 | 0.80–1.30 | ||
| Year (linear variable) | 1.03 | 1.00–1.06 | 0.031# | ||||
| Age group yrs | <0.001 | <0.001 | |||||
| 15–44 | 957/12082 (7.9) | 1 | 1 | ||||
| 45–64 | 177/3424 (5.2) | 0.63 | 0.54–0.75 | 0.70 | 0.59–0.83 | ||
| ≥65 | 61/2624 (2.3) | 0.28 | 0.21–0.36 | 0.34 | 0.26–0.44 | ||
| Sex | 0.098 | ||||||
| Male | 704/10258 (6.9) | 1 | |||||
| Female | 490/7845 (6.2) | 0.90 | 0.80–1.02 | ||||
| Place of reporting | <0.001 | <0.001 | |||||
| Outside London | 534/10506 (5.1) | 1 | 1 | ||||
| London | 661/7624 (8.7) | 1.77 | 1.58–1.99 | 1.52 | 1.34–1.72 | ||
| Ethnic group | <0.001 | <0.001 | |||||
| White | 193/4644 (4.2) | 1 | 1 | ||||
| Black Caribbean | 91/568 (16.0) | 4.40 | 3.37–5.74 | 3.11 | 2.36–4.08 | ||
| Black African | 324/4111 (7.9) | 1.97 | 1.64–2.37 | 1.22 | 1.00–1.50 | ||
| Indian/Pakistani/Bangladeshi | 400/6572 (6.1) | 1.49 | 1.25–1.78 | 1.18 | 0.99–1.42 | ||
| Other | 168/2009 (8.4) | 2.10 | 1.70–2.61 | 1.40 | 1.12–1.76 | ||
| Place of birth (time since entry into the UK) | 0.002 | ||||||
| UK | 275/4999 (5.5) | 1 | |||||
| Abroad (<2 yrs) | 182/2469 (7.4) | 1.37 | 1.13–1.66 | ||||
| Abroad (≥2 yrs) | 562/7974 (7.0) | 1.30 | 1.12–1.51 | ||||
| Abroad (unknown) | 116/1781 (6.5) | 1.20 | 0.96–1.50 | ||||
| Site of disease | 0.307 | ||||||
| Extrapulmonary | 427/6170 (6.9) | 1 | |||||
| Pulmonary sputum smear positive | 415/6287 (6.6) | 0.95 | 0.83–1.09 | ||||
| Other pulmonary | 350/5628 (6.2) | 0.89 | 0.77–1.03 | ||||
Resistance data are presented as number of resistant cases/total number of cases (%). OR: odds ratio; CI: confidence interval; AOR: adjusted OR. #: test for trend.