Gene | Rs number | Alleles# | Genotype | Source | Pooled | PIAMA | PREVASC | KOALA |
CD14 | rs2563298 | C/A | 3′UTR | I.I. | 0.27 | 0.28 | 0.29 | 0.27 |
CD14 | rs2569190 | C/T | -159C/T | I.I., lit | 0.48 | 0.47 | 0.46 | 0.49 |
CD14 | rs2569191 | T/C | -1145T/C | I.I., lit | 0.48 | 0.47 | 0.47 | 0.49 |
CD14 | rs2915863 | T/C | -1619T/C | I.I., lit | 0.41 | 0.40 | 0.38 | 0.42 |
CD14 | rs5744455 | C/T | -550C/T | I.I., lit | 0.23 | 0.23 | 0.24 | 0.23 |
IL13 | rs1295685 | C/T | 3′UTR | lit, HM | 0.20 | 0.20 | 0.20 | 0.20 |
IL13 | rs20541 | G/A | Arg130Gln | lit, HM | 0.20 | 0.20 | 0.21 | 0.20 |
IL13 | rs1881457 | A/C | -1512A/C | lit | 0.20 | 0.20 | 0.17 | 0.21 |
IL13 | rs1800925 | C/T | -1111C/T | lit | 0.20 | 0.20 | 0.18 | 0.20 |
Allele frequencies were similar between the cohorts (Chi-squared test; p>0.05) and genotypes were in Hardy–Weinberg equilibrium (p≥0.01). PIAMA: Prevention and Incidence of Asthma and Mite Allergy 15; PREVASC: Prevention of Asthma in Children 16, 17; KOALA: Child, Parent, Health, Focus on Lifestyle and Predisposition 18; IL: interleukin; UTR: untranslated region. I.I.: innate immunity website 26; lit: literature; HM: HapMap database 27. #: major alleles first, followed by minor alleles.