Table 5—

Negative binomial regression of chronic obstructive pulmonary disease exacerbation rates

EstimateStandard error95% CIp-value
rs2118177-0.300.12-0.5– -0.070.01
 Age-0.030.01-0.05– -0.0050.02
 FEV1 % pred-0.030.01-0.05– -0.010.01
 Treatment group#-0.550.19-0.9– -0.180.004
 Smoking historypack-yrs0.0030.003-0.004–0.010.4
 Sex-0.140.19-0.5–0.20.5
rs2304566-0.370.12-0.6– -0.10.002
 Age-0.030.01-0.05– -0.0040.02
 FEV1 % pred-0.030.01-0.05– -0.0080.007
 Treatment group#-0.520.19-0.9– -0.20.005
 Smoking history pack-yrs0.0030.003-0.004–0.010.4
 Sex-0.170.18-0.5–0.190.4
rs1130866-0.230.1-0.42– -0.040.02
 Age-0.030.01-0.05– -0.0050.02
 FEV1 % pred-0.030.01-0.05– -0.0070.01
 Treatment group#-0.500.2-0.9– -0.10.008
 Smoking history pack-yrs0.0030.003-0.004–0.010.4
 Sex-0.120.19-0.5–0.30.5
rs3024791-0.610.18-1.0– -0.30.0007
 Age-0.030.01-0.05– -0.0050.02
 FEV1 % pred-0.030.01-0.05– -0.0080.009
 Treatment group#-0.530.19-0.9– -0.20.006
 Smoking history pack-yrs0.0030.003-0.004–0.010.4
 Sex-0.100.19-0.5–0.20.5
rs20770790.010.12-0.2–0.20.9
 Age-0.030.01-0.05– -0.0040.02
 FEV1 % pred-0.030.01-0.05– -0.0050.02
 Treatment group#-0.500.19-0.9– -0.10.01
 Smoking history pack-yrs0.0020.003-0.004–0.010.5
 Sex-0.10.19-0.5–0.30.6
  • CI: confidence interval; FEV1: forced expiratory volume in one second; % pred: % predicted. #: underwent lung volume reduction surgery = 1 and received medical therapy = 0; : male = 1 and female = 0.