Present study | First author [ref.] | ||||
Vrijlandt 18 | Doyle 19 | Halvorsen 17 | Northway 15 | ||
Perinatal inclusion criteria | Birthweight <1500 g, dependent on supplementary O2 >36 weeks PMA | Birthweight <1500 g and/or gestation <32 weeks | Birthweight <1500 g | Birthweight <1000 g or gestation <28 weeks | Respiratory distress, dependent on supplementary O2 >28 days post-partum, CXR changes |
Minimum BPD severity | Moderate | Mild | Moderate | Moderate | Mild |
Subjects n | 21 (all with moderate or severe BPD) | 42 (9 with BPD)# | 147 (33 with moderate or severe BPD)¶ | 46 (36 with BPD, 12 moderate or severe)+ | 26 (all with BPD) |
Birthweight g | 914 (635–1355) | 1246 (720–1750)§ | 909 | 887 | 1894 |
Gestational age weeks | 27 (24–30) | 30 (26–36)§ | 26.8 | 27 | 33.2 |
Age when tested yrs | 20.3 (17–33) | 19 | 19.4 | 18.3 | 18.3 |
FEV1 % pred | 89.0 (22.6–121.9) | 90.1 | 81.6 | 87.8 | 74.8 |
FEF25–75% % pred | 63.7 (6.1–117.2) | 75.3 | 57.5 | 71.8 | 46.5 |
RV % pred | 95.8 (41.9–294.4) | 122.7 | 108.7 | 123.5 | 121.9ƒ |
TLC % pred | 106 (82.9–136.3) | 102.2 | 99.4 | 108.3 | 108.6 |
Data are presented as mean or median (range), unless otherwise specified. FEV1: forced expiratory volume in one second; % pred: % predicted; FEF25–75%: forced expiratory flow at 25–75% of forced vital capacity; RV: residual volume; TLC: total lung capacity; PMA: post-menstrual age; CXR: chest radiograph. #: data for the entire cohort; ¶: data for the BPD group only; +: data for the moderate or severe BPD group only; §: mean (range); ƒ: RV/TLC.