OR (95% CI) | p-value | |
Age <65/≥65 yrs | 5.03 (3.34–7.56) | <0.001 |
Comorbid condition | ||
Chronic pulmonary disease | 1.104 (0.80–1.53) | 0.560 |
Chronic heart disease | 2.76 (2.01–3.78) | <0.001 |
Congestive heart failure | 4.91 (3.56–6.78) | <0.001 |
Cerebrovascular disease | 5.91 (4.25–8.22) | <0.001 |
Other neurological disorder | 3.86 (2.61–5.69) | <0.001 |
Chronic liver disease | 2.98 (1.67–5.29) | 0.001 |
Chronic kidney failure | 4.22 (2.86–6.22) | <0.001 |
Diabetes mellitus | 2.55 (1.83–3.57) | <0.001 |
Nursing home | 8.00 (5.66–11.30) | <0.001 |
CURB score# | 2.60 (2.10–3.20) | <0.001 |
Change of antibiotic treatment | ||
Overall | 1.30 (0.90–1.83) | 0.186 |
Ineffectiveness | 2.24 (1.50–3.34) | 0.001 |
Sequential therapy | 0.46 (0.24–0.94) | 0.026 |
De-escalation | 0.40 (0.13–1.27) | 0.159 |
Intolerance | 1.52 (0.46–5.02) | 0.457 |
Resistance | 0.94 (0.93–0.95) | 0.258 |
OR: odds ratio; CI: confidence interval; CURB: confusion, urea, respiratory frequency and blood pressure. #: univariate analysis performed as logistic regression; OR and 95% CI shown are per step.