Table 3—

Comorbid conditions, residence status and treatment changes

	Age group		p-value
	<65 years	≥65 years	p-value
Subjects n	1298	1349
CURB score	0.55±0.73	1.03±0.89	<0.001
Comorbid condition
Chronic pulmonary disease	30.0	42.6	<0.001
Chronic heart disease	12.8	47.2	<0.001
Congestive heart failure	6.4	37.9	<0.001
Chronic liver disease	3.9	3.3	0.46
Chronic kidney failure	2.9	13.3	<0.001
Cerebrovascular disease	4.1	22.3	<0.001
Other neurological disorder	6.6	10.1	0.001
Diabetes mellitus	8.3	28.1	<0.001
Nursing home	3.3	15.2	<0.001
30-day mortality	2.2	10.3	<0.001
Change of antibiotic treatment
Overall	25.4	32.6	<0.001
Ineffectiveness	10.9	11.6	0.58
Sequential therapy	8.2	13.1	<0.001
De-escalation	3.8	4.8	0.13
Intolerance	1.3	1.2	0.86
Resistance	0.7	1.7	0.03

Data are presented as mean±sd or %, unless otherwise stated. CURB: confusion, urea, respiratory frequency and blood pressure.