Demographic and lung function characteristics of chronic obstructive pulmonary disease patients and age-matched healthy subjects
| Healthy | GOLD | |||
| Stage II | Stage III | Stage IV | ||
| Subjects n | 11 | 14 | 14 | 14 |
| Age yrs | 61±11 | 67±7 | 64±8 | 58±7 |
| Sex M/F n | 8/3 | 8/6 | 9/5 | 10/4 |
| Height cm | 161±8 | 168±8 | 165±6 | 169±9 |
| Weight kg | 70±13 | 77±34 | 67±8 | 68±10 |
| BMI kg·m−2 | 26.6±3.53 | 26.0±4.16 | 24.8±3.15 | 23.8±2.46 |
| FEV1 L | 3.12±0.92 | 1.61±0.35# | 1.11±0.23#,¶ | 0.71±0.14#,¶,+ |
| FEV1 % pred | 98±13 | 61±8# | 42±4#,¶ | 24±3#,¶,+ |
| FVC L | 4.26±0.82 | 3.17±0.69# | 2.63±0.72#,¶ | 2.61±0.74#,¶ |
| FVC % pred | 106±17 | 93±14 | 80±17#,¶ | 69±14#,¶ |
| FEV1/FVC % | 75±10 | 51±6# | 44±10#, ¶ | 28±5#,¶,+ |
| FEF25–75% L·s−1 | 2.73±1.52 | 0.62±0.27# | 0.36±0.13#,¶ | 0.24±0.07#,¶ |
| FEF25–75% % pred | 93±51 | 26±12# | 13±5#,¶ | 8±4#,¶ |
| DL,CO % pred | 81±38 | 61±23# | 46±14#,¶ | 32±12#,¶,+ |
| TLC L | 6.16±0.97 | 7.46±1.15 | 6.98±0.86 | 8.35±1.82# |
| TLC % pred | 97±11 | 119±12 | 117±12 | 133±22# |
| FRC L | 3.22±0.92 | 5.11±0.73# | 5.19±0.67# | 6.28±1.14#,¶ |
| FRC % pred | 96±12 | 153±19# | 162±14# | 196±36#,¶ |
| RV L | 1.93±0.77 | 3.88±0.62# | 4.27±0.70#,¶ | 4.92±0.98#,¶ |
| RV % pred | 88±31 | 169±27# | 186±28#,¶ | 244±46#,¶ |
| IC L | 2.86±0.91 | 2.15±0.61# | 2.02±0.38#,¶ | 2.00±0.89#,¶ |
| IC % pred | 92±24 | 80±16# | 65±12#,¶ | 66±20#,¶ |
Data are presented as mean±sd, unless otherwise stated. GOLD: Global Initiative for Chronic Obstructive Lung Disease; M: male; F: female; BMI: body mass index; FEV1: forced expiratory volume in one second; % pred: % predicted; FVC: forced vital capacity; FEF25–75%: mean forced expiratory flow between 25 and 75% of FVC; DL,CO: diffusing factor of the lung for carbon monoxide; TLC: total lung capacity; FRC: functional residual capacity; RV: residual volume; IC: inspiratory capacity. #: p<0.05 compared with healthy subjects; ¶: p<0.05 compared with GOLD stage II patients; +: p<0.05 compared with GOLD stage III patients.