Table 5—

Methodological quality rating scales for trials of different antibacterials in outpatient-treated community-acquired pneumonia

[Ref.]Inc/Exc#Truly randomisedGroups comparable+Intervention clear§Comparable careƒBlinding##OutcomesFollow-up appropriate§§ITTƒƒTotal###
Clear¶¶Appropriate++
1810.50.510110.33106.33
2010.50.510110.67106.67
19110.510110.67118.17
1210.50.510110.67106.67
910.50.5100.6710.67106.34
1610.5010110.6710.56.67
150.510.510010.33116.33
1710.51100.670.50.33106
10110.5100.6710.67106.84
2110.50.5100.6710.33106
1110.5110110.67118.17
1410.50.510110.67117.67
1310.50.510110.33117.33
  • Inc: inclusion; Exc: exclusion; ITT: intention to treat. #: 1: clearly defined; 0.5: inadequately defined; : 1: yes (clearly described, including concealed potential allocation); 0.5: unclear; +: 1: yes; 0.5: inadequately described; 0: obvious differences; §: 1: interventions clearly defined and applied via standardised protocol; 0: intervention poorly or not defined; ƒ: 1: care programmes, other than trial options, identical; 0.5: clear but trivial differences; 0: not mentioned or important differences; ##: 1: patients, treatment providers and outcome assessors blinded to treatment group; 0.67: two of three blinded; 0.33: one of three blinded; 0: no blinding or not mentioned; ¶¶: 1: outcomes clearly defined; 0.5: inadequately defined; 0: not defined; ++: 1: outcomes include clinical success, mortality and length of stay; 0.67: includes any two; 0.33: includes any one; 0: none; §§: 1: follow-up active and of appropriate duration (>3 weeks); 0.5: active, inadequate duration; 0: not active or not defined; ƒƒ: 1: outcomes of patients who withdrew described and included in ITT analysis; 0.5: inadequately described; 0: no mention or obvious differences; ###: maximum 10. Adapted from 8.